Description
Product Characteristics: USP6, ubiquitin specific peptidase 6 (Tre-2 oncogene), HRP1, TRE17, TRE2, Tre-2, USP6-short, OTTHUMP00000125301, deubiquitinating enzyme 6, hyperpolymorphic gene 1, proto-oncogene TRE-2, tre-2 oncogene, ubiquitin carboxyl-terminal hydrolase 6, ubiquitin specific peptidase 6-, ubiquitin specific protease 6 (Tre-2 oncogene), ubiquitin thioesterase 6, ubiquitin thiolesterase 6, ubiquitin-specific protease USP6, ubiquitin-specific-processing protease 6
Target Information: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation